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Windows defender and other antiviruses won't keep you 100% safe

This ^

Having antivirus, anti-exploit, anti-malware and anti-ransomware software actively monitoring your system, certainly helps prevent Intrusions but not In It's entirety.

https://www.hitmanpro.com/en-us/alert.aspx

Hitman Pro Alert has some great anti-exploit wrapper which protects current applications, and also some ransomware protection. But I havent tested the ransomware protection.

It did stop an exploit againt WaterFox though! So the anti-exploit might gaurd you from ever getting a ransomware in the first place.