[Eclipse]

Being used and being "exhausted" for all the wrong reasons, are completely different.

For example, If a given application was responsible for a memory leak, thus consuming all of the available/free Ram and then hitting the Page file (Virtual memory) leaving almost no memory available for critical tasks, then that's certainly a cause for concern- as this can cause significant system Instability and/or crashes.
Given Ram Is volatile (hence a reboot will discharge the Ram and revert to It's peak state), If the problematic application Is still there, memory will be consumed within a matter of minutes.

I use Adblock, and have been doing so for quite a while. I haven't noticed an abnormal usage of RAM and certainly not enough to impact performance.

Given the way that Chrome works, a separate process for every tab, a lot of RAM is being used anyway. But, as I said, RAM was made to be used and Adblock causes me no concern.