[Dismas]

An actual spoiler, but...

Spoiler:

It's assumed David got killed by Adam Smasher. At the very end of the show Adam Smasher says something to the tune of: "You could prove an interesting construct." Given the show is set a year before the events of 2077, it's likely constructs already exist and David could return as stored consciousness (like Johnny Silverhand). This would be with the assumption his consciousness was stored during the installation of the exoskeleton/ambush. In both the game and the show, the protagonist's initial goal was to reach the top of Arasaka tower (Johnny and David both succeeded). A sequel seems almost inevitable since Lucy and Falco are still alive.