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HIV: First woman in world believed to be cured of virus - pippin - 02-18-2022

A US patient is believed to be the third person in the world, and first woman, to be cured of HIV.


[Image: _123278420_mediaitem123278419.jpg]

The patient was being treated for leukaemia when she received a stem cell transplant from someone with natural resistance to the Aids-causing virus.

The woman has now been free of the virus for 14 months.

But experts say the transplant method used, involving umbilical cord blood, is too risky to be suitable for most people with HIV.

The patient's case was presented at a medical conference in Denver on Tuesday and is the first time that this method is known to have been used as a functional cure for HIV.

The patient received a transplant of umbilical cord blood as part of her cancer treatment and has since not needed to take the antiretroviral therapy required to treat HIV.

The case was part of a larger US study of people living with HIV who had received the same type of blood transplant to treat cancer and serious diseases.

The transplanted cells that were selected have a specific genetic mutation which means they can't be infected by the HIV virus.

Scientists believe the immune system of recipients can develop resistance to HIV as a result.
All HIV cure stories are genuinely remarkable and a cause for celebration - they prove that it can be done.

But this approach does not bring us closer to a cure for the 37 million people living with HIV, most of whom live in sub-Saharan Africa.

The potential of stem cell transplants was demonstrated in 2007 when Timothy Ray Brown was the first person to be "cured" of HIV. He had a transplant from a donor who was naturally resistant to HIV.

Since then the feat has been repeated only twice with Adam Castillejo and now the New York patient.

All three had cancer and needed a stem cell transplant to save their lives. Curing their HIV was never the primary goal and the therapy is too risky to use on everybody with HIV.

Remember, anti-retroviral therapy gives people with HIV a near-normal life expectancy.

The main hopes of a cure remain focused on vaccines or drugs that can flush the virus out of the body.
The woman's treatment involved umbilical cord blood, unlike the two previous known cases where patients had received adult stem cells as part of bone marrow transplants.

Umbilical cord blood is more widely available than the adult stem cells previously used and it does not require as close a match between donor and recipient.

Sharon Lewin, president-elect of the International Aids Society, cautioned that the transplant method used in this case wouldn't be a viable cure for most people living with HIV.

But she added that the case "confirms that a cure for HIV is possible and further strengthens using gene therapy as a viable strategy for an HIV cure."

The findings around this most recent case study are yet to be published in a peer-reviewed journal, so wider scientific understanding is still limited.

https://bbc.co.uk/news/health-60394306

RE: HIV: First woman in world believed to be cured of virus - Dismas - 02-20-2022

Stem cell research is definitely the way forward. Not just for AIDs, but also regenerative purposes.

RE: HIV: First woman in world believed to be cured of virus - Boudica - 02-20-2022

(02-20-2022, 03:00 AM)Dismas Wrote: Stem cell research is definitely the way forward. Not just for AIDs, but also regenerative purposes.

Stem cell research is just incredible. I wonder where it will take us another 50 years down the line. Will these ultra-rare treatments become the norm?

RE: HIV: First woman in world believed to be cured of virus - mothered - 02-20-2022

(02-20-2022, 08:31 AM)Boudica Wrote: Stem cell research is just incredible. I wonder where it will take us another 50 years down the line. Will these ultra-rare treatments become the norm?
I believe so.

I'd say It's safe to assume that 50 years down the track, the treatments will no longer be ultra-rare.

RE: HIV: First woman in world believed to be cured of virus - Geofront - 02-25-2022

ehm, I wonder how is that possible

RE: HIV: First woman in world believed to be cured of virus - billyferg - 02-26-2022

(02-20-2022, 08:31 AM)Boudica Wrote:
(02-20-2022, 03:00 AM)Dismas Wrote: Stem cell research is definitely the way forward. Not just for AIDs, but also regenerative purposes.

Stem cell research is just incredible. I wonder where it will take us another 50 years down the line. Will these ultra-rare treatments become the norm?

I always wonder that about these new things. I feel like I always see that there is some breakthrough new treatment for this or that, but then I never hear about it again or see it. I don't know what it takes to get things to the mainsteam.

RE: HIV: First woman in world believed to be cured of virus - Boudica - 02-27-2022

(02-26-2022, 04:21 AM)billyferg Wrote:
(02-20-2022, 08:31 AM)Boudica Wrote:
(02-20-2022, 03:00 AM)Dismas Wrote: Stem cell research is definitely the way forward. Not just for AIDs, but also regenerative purposes.

Stem cell research is just incredible. I wonder where it will take us another 50 years down the line. Will these ultra-rare treatments become the norm?

I always wonder that about these new things. I feel like I always see that there is some breakthrough new treatment for this or that, but then I never hear about it again or see it. I don't know what it takes to get things to the mainsteam.

A lot of time and money. And sometimes luck too. There's a big difference between something that is possible, and something that the average person, aka millions - billions of people can have access to. Some stuff is researched for decades with the intent to put it into action only when needed. The covid vaccines are a fine example of this. 10+ years of development so these things can be mass produced at speed when needed. However, if there isn't a global crisis or enough clearance for clinical trials, it can take 30 years, or never happen at all.

RE: HIV: First woman in world believed to be cured of virus - theovonenjoyer - 05-21-2023

is that even possible lol

RE: HIV: First woman in world believed to be cured of virus - hanqifeng - 05-22-2023

Good good good good good Good good good good good

RE: HIV: First woman in world believed to be cured of virus - alexman05 - 11-22-2023

Wow that’s amazing. Really well done. Only that I’m hearing about it not on source of media owned by the government, but on a very unknown forum site.