Login Register






Thread Rating:
  • 0 Vote(s) - 0 Average


so you think you're fucked up? filter_list
Author
Message
so you think you're fucked up? #1
Char syndrome is a condition that affects the development of the face, heart, and limbs. It is characterized by a combination of three major features: a distinctive facial appearance, a heart defect called patent ductus arteriosus, and hand abnormalities.

Most people with Char syndrome have a characteristic facial appearance that includes flattened cheek bones and a flat nasal bridge (the area of the nose between the eyes). The tip of the nose is also flat and broad. The eyes are wide-set with droopy eyelids (ptosis) and outside corners that point downward (down-slanting palpebral fissures). Additional facial differences include a shortened distance between the nose and upper lip (a short philtrum), a triangular-shaped mouth, and thick, prominent lips.

Patent ductus arteriosus is a common heart defect in newborns, and it occurs in most babies with Char syndrome. Before birth, the ductus arteriosus forms a connection between two major arteries (the aorta and the pulmonary artery). This connection normally closes shortly after birth, but it remains open in babies with patent ductus arteriosus. If untreated, this heart defect causes infants to breathe rapidly, feed poorly, and gain weight slowly. In severe cases, it can lead to heart failure. People with patent ductus arteriosus also have an increased risk of infection.

Hand abnormalities are another feature of Char syndrome. In most people with this condition, the middle section of the fifth (pinky) finger is shortened or absent. Other abnormalities of the hands and feet have been reported but are less common.
How common is Char syndrome?

Char syndrome is rare, although its exact incidence is unknown. Only a few families with this condition have been identified worldwide.
What genes are related to Char syndrome?

Mutations in the TFAP2B gene cause Char syndrome. This gene provides instructions for making a protein known as transcription factor AP-2β. A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Transcription factor AP-2β regulates genes that are involved in development before birth. In particular, this protein appears to play a role in the normal formation of structures in the face, heart, and limbs.

TFAP2B mutations alter the structure of transcription factor AP-2β. Some of these mutations prevent the protein from binding to DNA, while other mutations render it unable to regulate the activity of other genes. A loss of this protein's function disrupts the normal development of several parts of the body before birth, resulting in the major features of Char syndrome.

and lucky lucky for me i have it. FUCK.

Reply

RE: so you think you're fucked up? #2
Oh my god. i just read part's of this text, i cant read more since i read the last sentence.
Is it serious? Deadly? say something with your words.
Sad
Sorry brah Sad
Is it permanent?

Reply

RE: so you think you're fucked up? #3
yeah its permanent. from birth to death.

i was supposed to die before i was 5. but obviously that didnt happen, so i should be fine except for the obvious having it and what it does to me, i dont have all the symptoms, just some...O.o

Reply

RE: so you think you're fucked up? #4
Oh shit. That sucks. Well, I'm guessing it can be somewhat masked with extra production of testosterone.
[Image: nNICR.jpg]
Creds to bluedog

For a list of my contributions (includes tutorials). Click here.

If you'd like to apply for Heat, please click here.

Reply

RE: so you think you're fucked up? #5
thats what i'm hoping. so i want to be buff. but not too buff. my new could-be gf doesnt like abs :3

Reply

RE: so you think you're fucked up? #6
(03-10-2012, 11:24 PM)Reality Wrote: thats what i'm hoping. so i want to be buff. but not too buff. my new could-be gf doesnt like abs :3

What the fuck kind of girl doesn't like abs? She's probably lying from what I know. Not everything girls say are true.

But yeah, working out will definitely transform your face. Your jawline would be bigger and more defined, that's what's most important.
[Image: nNICR.jpg]
Creds to bluedog

For a list of my contributions (includes tutorials). Click here.

If you'd like to apply for Heat, please click here.

Reply

RE: so you think you're fucked up? #7
i think sharp cheekbones are sexy

and idk, she's goth, 16, hot as FUCK, i <3 her to bits though (:

Reply

RE: so you think you're fucked up? #8
(03-11-2012, 12:29 AM)Reality Wrote: i think sharp cheekbones are sexy

and idk, she's goth, 16, hot as fudge, i <3 her to bits though (:

Sharp cheekbones ARE sexy. You just have to work out, work out, and work out. LOL. My friend taught me a trick to work out your jaw.. Just tie a string to some dumbbells and attach it to your mouth, then slowly open and close your mouth.

Trust me.. There is NO straight girl that doesn't like abs, NONE. It's impossible. That's like saying that there are straight guys that don't like titties, it just doesn't happen..

And just a FYI, I've discovered that girls go for guys with higher testosterone levels (assholes, aggressive guys, muscular guys, tall guys).. And guys go for girls with higher progesterone levels (titties, ass, etc..).
[Image: nNICR.jpg]
Creds to bluedog

For a list of my contributions (includes tutorials). Click here.

If you'd like to apply for Heat, please click here.

Reply

RE: so you think you're fucked up? #9
i'm really tall :3

she showed me her tits actually yesterday :3

Reply

RE: so you think you're fucked up? #10

Smart, is that one of the symptoms?

Reply







Users browsing this thread: 1 Guest(s)